With medicinal Cannabis use steadily increasing, lab testing has rapidly become an industry standard. Certain labs allow their patients to see a breakdown of exact percentages of all Cannabinoids in their medicine. The shift from THC to other “minor” Cannabinoids is allowing for new discoveries to pop up almost daily.
Humans make stem cells, which are undifferentiated types of cells. Plants, specifically Cannabis here, seems to have something similar called Cannabigerolic Acid (CBGA). This Cannabinoid is the predecessor to the three major cannabinoids, THCA, CBDA, and Cannabichromenic Acid (CBCA). Plants have certain enzymes calls synthase; these enzymes catalyze a synthesis process where substrates, such as CBGA, are converted into more complex products such as THC or CBD. Chemists have found higher concentrations of CBGA in hemp, as high as 94% CBG. Studies have shown that this high concentration could be due to a recessive gene found in hemp that inhibits the synthesis that would further develop this cannabinoid.
This study suggests that it may help those with IBD, Glaucoma, may prevent depression, and help to inhibit further tumor growth.
The effects of Cannabigerol are somewhat limited. Due to the restrictions of Cannabis testing, it is difficult to find volumes of quality research. We do know that it is classified as a foe to the CB1 receptor. It is believed to counteract the paranoid “heady” high associated with THC which binds to this CB1 receptor. CBG may also have an effect on the CB2 receptor, however, researchers have not determined whether it promotes or inhibits the body influencing CB2 receptors. According to an Italian study published in May of 2013, it is suggested that Cannabigerol itself has a strong anti-inflammatory property. This study suggests that it may help those with IBD, Glaucoma, may prevent depression, and help to inhibit further tumor growth. Our brains release a chemical called GABA when stressed. When this chemical is inhibited from reaching its receptors, it can decrease anxiety as well as muscle tension. CBG is said to affect the brain in ways that it does inhibit GABA, causing an effect similar to what we would see with CBD.
Our favorite head high causing cannabinoid THC as well as life changing CBD all start off at Cannabigerol. Researchers are still studying the CBGs medicinal properties, helping them to understand how to utilize this cannabinoid to its full potential. Personally, the way I see the future of Cannabis, strains will be further developed to help specific conditions. Perhaps one day, the hemp stem cell will be able to be fully understood and harvested and grown into lifesaving Cannabinoids.